This seminal article by Zhang et al demonstrates the crucial role of CACs in delayed healing in general and in burns in particular. This report advances research in the wound field in that it provides a unique model that demonstrates a similar physiologic response of CACs in burned mice and in human patients with burn injuries. Despite the dissimilarities in magnitude and duration of CAC mobilization between the 2 populations, the authors demonstrate the importance of the study of CAC mobilization in the experimental and human groups.
Maggi J, Brem H. The Future of CACs in Wound HealingComment on “Association of Increasing Burn Severity in Mice With Delayed Mobilization of Circulating Angiogenic Cells”. Arch Surg. 2010;145(3):266. doi:10.1001/archsurg.2009.287