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Invited Critique
September 2010

Is Transfusion of ABO-Compatible Nonidentical Plasma Truly Associated With an Increased Risk of Complications?Comment on “Impact of ABO-Identical vs ABO-Compatible Nonidentical Plasma Transfusion in Trauma Patients”

Author Affiliations

Author Affiliation: Division of Trauma, Critical Care and Acute Care Surgery, Oregon Health [[amp]] Science University, Portland.

Arch Surg. 2010;145(9):906. doi:10.1001/archsurg.2010.181.1

The transfusion of high ratios of plasma and platelets to packed red blood cells, known as hemostatic resuscitation, in patients requiring massive transfusion has become a standard of care in many trauma systems. This is a result of multiple retrospective analyses from both military and civilian databases that showed an association between high-ratio transfusion and improved survival. This very well-done study by Dr Inaba and his colleagues from the University of Southern California raises critical questions concerning the safety of hemostatic resuscitation.

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