If you are one of those surgeons who believes that Darwin was correct, then you must also trust the constructive fortitude of an enzyme that has survived millennia of evolutionary hurdles. It must be doing something good. And the therapeutic arrogance of selectively inhibiting this enzymatic hall-of-famer should be dangerous—like challenging the pope on scripture. But, in this issue of the ARCHIVES, this is exactly what Hua et al have done.
Harken AH. Polyadenosine Diphosphate–Ribose Polymerase Inhibition Modulates Skeletal Muscle Injury Following Ischemia Reperfusion—Invited Critique. Arch Surg. 2005;140(4):352. doi:10.1001/archsurg.140.4.352