Thirty years have passed since Volkmann, in his epoch-making monograph on endotheliomas, pointed out that the discrepancy in the interpretation of tumors is due to the general attempts to classify them on the basis of their morphologic structure alone. He emphasized the necessity in all complex cases of tumors of studying the origin and the development of the tumor and not the cytology present and the arrangement of the cells alone. It is generally known that the differentiation of pathologically changed endothelial cells from epithelial cells is very difficult, if not impossible. There can be no question, however, that in such border line cases the study of the development of the tumor and the tracing of its origin can contribute much toward making a correct diagnosis.
It is usually considered that a primary endothelioma of the skeleton is incomparably more difficult to diagnose than nonskeletal endotheliomas. It is true that
KOLODNY A. A CASE OF PRIMARY MULTIPLE ENDOTHELIOMA OF BONEWITH SPECIAL EMPHASIS ON ITS ROENTGENOLOGIC FEATURES. Arch Surg. 1924;9(3):636–646. doi:10.1001/archsurg.1924.01120090153011