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March 1925


Author Affiliations

From the Laboratory for Surgical Research, Columbia University College of Physicians and Surgeons.

Arch Surg. 1925;10(2):756-763. doi:10.1001/archsurg.1925.01120110156008

In recent years, the subject of acute intestinal obstruction and its associated toxemia has aroused great interest among surgeons and laboratory investigators. From a clinical standpoint, the necessity for early diagnosis and prompt treatment has been firmly established. From the experimental standpoint, there has been much speculation concerning the nature of the toxemia of acute intestinal obstruction and the relative importance of various factors leading to a fatal outcome. Whipple1 and his co-workers have shown that acute intestinal obstruction is associated with an increase in the nonprotein nitrogen of the blood, an increase in urinary nitrogen and a depression of renal function. They believe that there is a profound intoxication in acute intestinal obstruction, due to the absorption of a highly toxic proteose from the obstructed intestine. Other workers have emphasized the significance of dehydration of the tissues. Haden and Orr2 have laid stress on the decrease in

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