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May 1926

THREE TUMORS ARISING FROM NEUROBLASTS

Author Affiliations

WINNIPEG, CANADA
From the departments of pathology of the University of Manitoba, the Winnipeg General Hospital and the Children's Hospital.

Arch Surg. 1926;12(5):1031-1048. doi:10.1001/archsurg.1926.01130050085004
Abstract

The neuroblastoma, a tumor arising from neuroblasts or primitive nerve cells, although still somewhat of a pathologic rarity, is commoner than used to be supposed. Many cases described in the literature as sarcoma of the suprarenal or of the liver, congenital tumor of the suprarenal with metastases in the liver, lymphosarcoma of the suprarenal, malignant hypernephroma of the suprarenal medulla, etc., are now known to have been examples of neuroblastoma. Moreover, it is more than probable that the numerous cases reported as retroperitoneal sarcoma in children are also to be included in this category. Wright1 saw five instances of the disease in a single year, and I have recently encountered four in a similar time. A necropsy was obtained on three of these, the results of which are presented here.

It was Virchow, in 1864, who first guessed at the nervous tissue origin of these congenital suprarenal tumors. He

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