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Article
October 1928

EFFECT OF INJECTIONS OF HYDROCHLORIC ACID ON THE GASTRIC AND DUODENAL MUCOSAE

Author Affiliations

CHICAGO
From the Seymour Coman Fellowship in the Department of Physiology of the University of Chicago and the Department of Surgery of Rush Medical College of the University of Chicago.

Arch Surg. 1928;17(4):613-626. doi:10.1001/archsurg.1928.01140100083005
Abstract

In a previous communication,1 it was shown that acute traumatic lesions of jejunal transplants to the stomach healed readily in the presence of artificial hyperacidity. I shall now report the changes observed in the gastric and duodenal mucosae of those experiments and further observations in a group of control animals fed acid solution.

EXPERIMENTAL PROCEDURE AND RESULTS  The experimental procedure was described in a previous report.Briefly, after recovery from the intestinal transplant operation, a group of seven animals were fed acid solution through a stomach tube once or twice daily in amounts of from 200 to 225 cc. and in concentrations of 0.22, 0.29 and 0.62 per cent by weight.A group of six control dogs was similarly studied, into which 0.62 per cent acid solution was injected two or three times daily. The injections were given daily from ten to eighty days. On various occasions, the contents

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