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Article
June 1929

PERFRINGENS ANTITOXIN AND EXPERIMENTAL INTESTINAL OBSTRUCTION

Author Affiliations

BALTIMORE
William Stewart Halsted Fellow in Surgery.

Arch Surg. 1929;18(6):2237-2245. doi:10.1001/archsurg.1929.01140150001001
Abstract

Though there had accumulated an extensive literature on the subject of anaerobes, and though much had been learned about gas gangrene from a surgical point of view, not only before but during the World War, it was only in 1918 that a polyvalent antitoxic serum1 was elaborated both for preventive and for curative use. In 1917, Bull and Pritchett2 proved beyond all doubt the practical value of B. welchii antitoxin, and thus led the way for the production of the polyvalent serum that contains not only the antitoxin to B. welchii, but to Vibrion septique and B. oedematiens as well. It has been chiefly since the war, therefore, in the rare occasions of civil practice, that the more efficient serum has been employed. It would seem from a fair number of cases reported that the efficacy of antigas gangrene serum was comparable to that of the antitoxin of

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