Mann,1 in 1921, first reported the production of specific cholecystitis by the intravenous injection of Dakin's solution (a solution of chlorinated soda). At that time, however, studies were not made on the emptying time of such acutely inflamed gallbladders, as there was no evidence to show that the gallbladder emptied. Many attempts were made to produce chemical cholecystitis by the use of a solution of chlorinated soda subsequent to the discovery that the gallbladder emptied after the ingestion of a meal of fat, but because of variation in the commercial product, positive results were not attained. In the light of present, recently acquired knowledge concerning the emptying of the normal gallbladder following a fat meal, I was prompted to determine whether or not an acutely inflamed gallbladder empties, and to what extent such emptying occurs following the ingestion of a meal rich in fat.
METHOD OF STUDY
MURPHY GT. THE EFFECT OF ACUTE EXPERIMENTAL CHOLECYSTITIS ON THE EMPTYING OF THE GALLBLADDER. Arch Surg. 1930;21(2):300-312. doi:10.1001/archsurg.1930.01150140117004