A toxic proteose fraction has been isolated by Whipple and his co-workers1 from the intestinal content obtained from patients with acute intestinal obstruction and from animals with obstruction experimentally produced. This observation has been confirmed by others, and the chemical nature of this fraction has been subjected to further investigation by Ingvaldsen and his co-workers.2 Ellis3 has been successful in isolating a toxic proteose fraction from the intestine of dogs dying from distemper, peritonitis and following operation on the adrenal gland and from animals dying from the administration of this material. The factors responsible for the production of this material and the rôle that it may play in various intoxications are unknown. It was thought that further information concerning its origin and significance might be obtained by investigating its occurrence in material from additional sources.
It is to be understood that the term, toxic proteose fraction, as
McCLINTOCK JT, HINES HM. OCCURRENCE OF A TOXIC PROTEOSE FRACTION IN MATERIAL FROM VARIOUS SOURCES. Arch Surg. 1930;21(5):860–864. doi:10.1001/archsurg.1930.01150170146008