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January 1932


Author Affiliations

From the Division of Experimental Surgery and Pathology, the Mayo Foundation.

Arch Surg. 1932;24(1):126-135. doi:10.1001/archsurg.1932.01160130129008

During the course of our studies on the experimental control of ascites, extending over several years, we have had occasion to observe a large number of dogs with complete obstructive jaundice. Many of these animals were lost to the original study because of the early development of perforated duodenal and gastric ulcers. Only a few studies have been made concerning ulcer complicating complete obstructive jaundice. Of the recent work bearing directly on the subject, Berg and Jobling1 (1930) found that in three of five animals, peptic ulcers developed following complete obstructive jaundice. In one dog multiple gastric erosions were encountered forty-seven days after ligation of the common bile duct. One hundred and eight days after operation, another animal had two perforated chronic duodenal ulcers, and the third dog had a single chronic duodenal ulcer after one hundred and eighty-nine days. These authors also often found peptic ulcers in animals

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