Numerous studies have been made in order to link osteogenesis and bony repair after fracture with calcium metabolism. Other studies have been concerned with attempts to explain nonunion after fracture on the basis of alteration in the serum calcium and phosphorus values. In the present work a detailed study of alterations in the calcium, inorganic phosphorus and protein values of the blood serum in experimental fractures was made through the administration of graded doses of viosterol.
The relationship of vitamin D to calcium metabolism has been generally accepted since the work of McCollum in 1922. With the advent of viosterol an opportunity was afforded to study this substance in its relationship to osteogenesis. The calcium salts are intimately bound up with bone formation in the fetus, with bone repair in the adult and with bony metaplasia. There is little wonder that the obvious association was seized on by numerous workers.
GRAUER RC. THE EFFECT OF VIOSTEROL ON THE PERIOSTEUM IN EXPERIMENTAL FRACTURES. Arch Surg. 1932;25(6):1035–1054. doi:10.1001/archsurg.1932.01160240027002