The scientific explanation of the hemorrhagic tendency in patients suffering with jaundice has been energetically sought for by a great number of investigators, some of whom are apparently definitely convinced by the results of their experimental work that the problem is settled. It is difficult for one reviewing the literature to come to any definite conclusion in his own mind relative to this phenomenon, because of the wide diversity of opinions and because of the conflicting data in the literature.
The fibrinogen content of the blood plasma has not been investigated carefully from an experimental standpoint as a possible cause for this hemorrhage, and it was with that in mind that the work herein submitted was done in an attempt to arrive at some solution of this perplexing and vexing problem.
After considering this subject theoretically, it seems that the hemorrhagic tendency in these patients might be attributed to the
MOSS W. EXPERIMENTAL OBSTRUCTIVE JAUNDICEITS EFFECT ON FIBRINOGEN AND COAGULATION OF THE BLOOD. Arch Surg. 1933;26(1):1–19. doi:10.1001/archsurg.1933.01170010004001