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May 1933


Author Affiliations

From the Department of Physiology and Pharmacology, Northwestern University Medical School.

Arch Surg. 1933;26(5):750-764. doi:10.1001/archsurg.1933.01170050018002

An attempt to increase the utilization of carbohydrates by surgical means may follow various courses. It may try to stimulate the formation of islets in the pancreas and increase the insulin output of the gland. If one regards the insulin deficiency as the primary cause of diabetes, an increase of insulin production would be highly desirable. Minkovski's1 belief that the diabetic organism is unable to utilize carbohydrate has been greatly strengthened by the isolation of insulin, and seemingly gave the final blow to the alternate theory of diabetes, emphatically upheld by von Noorden2 since 1910, namely, that hyperglycemia and glycosuria are due to an overproduction of sugar, owing to a hyperirritability of the sugar-producing apparatus in the liver. This theory naturally emphasizes the nervous regulation of carbohydrate metabolism and would call for an attack on the nerve supply of organs that are effecting the utilization of carbohydrates. Our

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