The exact etiology of osteochondritis of the head of the femur1 is still undetermined. Various theories of the cause of this disease have been advanced, the most reasonable of which may be considered under the headings of infection, trauma, embolism and maldevelopment.
The evidence in favor of infection as the etiologic agent is based on a few bacteriologic studies. Legg2 scraped tissue from a large area of rarefaction in the neck of the femur of a patient suffering from this disease and found that staphylococci grew in cultures from the material so obtained. Kidner3 obtained staphylococci from the granulation tissue found in necrotic areas in the metaphyseal region of the upper end of the femur in a similar case. McWhorter4 likewise found the staphylococcus in a single case. Phemister5 removed part of the upper femoral epiphysis after curetting the interior, and obtained no microbic growth
MILTNER LJ, HU CH. OSTEOCHONDRITIS OF THE HEAD OF THE FEMURAN EXPERIMENTAL STUDY. Arch Surg. 1933;27(4):645-657. doi:10.1001/archsurg.1933.01170100019002