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Article
November 1933

HEALING OF FRACTURES AND BONE DEFECTS AFTER VENOUS STASIS

Author Affiliations

ST. LOUIS
From the Department of Surgery, Washington University School of Medicine.

Arch Surg. 1933;27(5):935-940. doi:10.1001/archsurg.1933.01170110120010
Abstract

In this paper we shall report a series of observations on the healing of fractures or of defects in both ulnae of the dog when the veins draining one foreleg are ligated, thus creating marked venous stasis in that leg.

REVIEW OF THE LITERATURE  The literature on the effect of venous stasis on osteogenesis has been reviewed by Pearse and Morton,1 who trace the use of hyperemia from the time of Ambroise Paré. The clinical observations in the literature stimulated these authors to study the subject experimentally. They created a small defect in the fibula of each hind leg and ligated the right popliteal vein in twelve dogs. The ligation of this vein caused venous stasis in the region of the experimental bone defect in that fibula. In eleven of the twelve dogs, union was accelerated on the side of the ligation; this was manifested by the earlier formation

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