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February 1934


Author Affiliations


Arch Surg. 1934;28(2):307-316. doi:10.1001/archsurg.1934.01170140087005

For more than twenty years I have been acutely sensible of the fact that certain globular cancers of the breast present a particularly bad prognosis. In addition to their external form, they present a varied histologic structure which requires the assumption of a wide latitude of cell metaplasia to keep them within the group of epithelial tumors.

Recently I encountered a patient whose tumor seemed to be a connecting link between the aforementioned group and the intracanalicular fibro-adenomas. As the cells of this tumor seemed to spring from its subepithelial cells, I am calling growths of this type chromatophore tumors, realizing that this is little more than a symbol. Since they do not produce pigment, one cannot call them melanomas, though they duplicate the histologic structure of the pigmented tumors in a striking manner. Amelanotic melanomas would be a more accurate though cumbersome designation.

The use of a term suggesting

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