Although the literature on avertin (tribromethanol) rectal anesthesia has become voluminous since the production of the chemical compound tribromethanol by Willstätter and Duisberg, in 1923, there are only a few investigations on the effects in normal persons of the drug administered alone, in the dosage used in basal anesthesia. Before we were willing to employ avertin anesthesia on a large scale in hospital practice, we deemed it advisable to investigate the effects of the drug in normal persons. The numerous reports recorded present either experiments on animals or observations on persons with such complicating factors as operation, auxiliary medication and supplementary anesthesia.
We studied avertin anesthesia in fifteen normal people with a view to obtaining information on the uncomplicated effects of the drug. We made observations on the following: age, sex, weight, dosage, constitution, pulse, temperature, respiratory rate and amplitude, condition of the reflexes, state of consciousness, presence of
ARNHEIM EE, TUCHMAN LR. AVERTIN (TRIBROMETHANOL) ANESTHESIA IN NORMAL PERSONS. Arch Surg. 1934;29(1):1-15. doi:10.1001/archsurg.1934.01180010004001