In a previous communication, Garside and one of us (A. O.)1 reported the results of studies on the effect of the intravenous injection of certain sclerosing solutions. The present paper is in reality a report of the continuation of that work, comprising a similar study of nine additional solutions. The twenty solutions in the first study and the nine in the present study include practically all the important drugs advocated for use in the treatment of varicose veins by injection and in addition certain new drugs that have not been used before for this purpose, either experimentally or clinically. Comparison of the results shows the relative value of the solutions in their potency as thrombosing agents producing changes in the walls of the veins.
The solutions used in this investigation were 10 and 5 per cent solutions of sodium morrhuate (our own); 5, 3 and 2 per cent solutions
OCHSNER A, MAHORNER H. COMPARATIVE VALUE OF INTRAVENOUS SCLEROSING SUBSTANCES. Arch Surg. 1934;29(3):397–416. doi:10.1001/archsurg.1934.01180030062005