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Article
January 1935

EFFECT OF SUPRARENAL DENERVATION AND SPLANCHNIC SECTION ON THE SUGAR TOLERANCE OF DOGS

Author Affiliations

CHICAGO
From the Department of Physiology and Pharmacology, Northwestern University Medical School.

Arch Surg. 1935;30(1):151-161. doi:10.1001/archsurg.1935.01180070154008
Abstract

In a previous study1 we found that the removal of the celiac ganglion resulted in a decided, persistent rise of tolerance in every instance. The dogs became more sensitive to insulin. A denervation of the liver did not produce a rise in tolerance. To analyze the mechanism of our previous results, the rôle of the suprarenal glands was investigated in the study to be reported here.

Elsewhere2 we summarized the literature on the effect of suprarenal denervation and of splanchnic section on sensitivity to insulin. It was reported uniformly that removal of the medulla, denervation of suprarenal glands or bilateral splanchnic section renders the animals more sensitive to insulin. The determination of hypersensitivity to insulin was only roughly quantitative, the criterion being whether convulsion occurred with a dose of insulin which prior to the operative procedure failed to cause convulsion. Regarding sugar tolerance before and after suprarenal denervation

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