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Article
April 1935

HISTOLOGIC EFFECTS OF INTRAVENOUS SCLEROSING SOLUTIONS ON SUBCUTANEOUS TISSUES

Author Affiliations

NEW ORLEANS
From the Department of Surgery, Tulane University School of Medicine.

Arch Surg. 1935;30(4):573-583. doi:10.1001/archsurg.1935.01180100019003
Abstract

Injection into varicose veins of the lower extremities has become the most popular and is undoubtedly the best method of treatment in most cases. In a previous paper by Garside and one of us (Ochsner)1 and in a previous paper by us2 the results of histologic studies of the effects of intravenous injection of twenty-nine sclerosing solutions are reported in detail. In each of those papers attention was called to the fact that the endothelium was partially or completely destroyed by an effective thrombosis-producing agent, and mention was made of the fact that such destruction was essential for the precipitation of a thrombus. In our last paper2 we also showed that the effect of some sclerosing agents was not only the destruction of the intima but also at times the production of coagulation necrosis of the media. The intima, when sufficiently injured, disappeared so that it was

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