Almost a century ago, Cruveilhier1 distinguished between peptic ulcer and carcinoma of the stomach and expressed the opinion that in certain cases malignant degeneration of a peptic ulcer might occur. Since then a voluminous literature, more or less controversial, has accumulated on the question of malignant degeneration of a preexisting benign ulcer of the stomach. It is now generally conceded that so-called "ulcer-carcinoma"2 does exist as a pathologic entity. The point about which discussion still centers, however, is the incidence of such a lesion.
Cabot and Adie3 reviewed 82 reports in the literature and noted that approximately half the authors concluded that the development of carcinoma from ulcer occurs in less than 10 per cent of cases.
Newcomb,4 in a comprehensive survey, listed the statistics of 102 observers who estimated the proportion of gastric carcinomas originating in primary benign ulcers. Among these, 51 stated that not
KLEIN SH. ORIGIN OF CARCINOMA IN CHRONIC GASTRIC ULCER. Arch Surg. 1938;37(1):155-174. doi:10.1001/archsurg.1938.01200010160011