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Article
August 1938

CARCINOMA OF THE BREASTREVIEW OF FOUR HUNDRED AND THIRTY-NINE CASES

Author Affiliations

SAYRE, PA.
From the Guthrie Clinic.

Arch Surg. 1938;37(2):190-210. doi:10.1001/archsurg.1938.01200020018002
Abstract

ETIOLOGY AND SUSCEPTIBILITY  The cause of mammary cancer, in common with that of other types of malignant tumor, is not definitely known. Even though many facts have been learned, mammary cancer appears to have reached a point beyond which effective prevention seems well nigh impossible.Chronic mastitis is believed by most authorities to be the principal predisposing condition, but cancer so often occurs without pronounced chronic mastitis or in a very early stage of mastitis that this theory in itself is inadequate to explain the frequent incidence. All will agree, however, that mammary cancer must be preceded by involutional or inflammatory changes. The sweat glands of the breast are frequently the site of origin, and the causation of lesions so originating is probably somewhat different from that of the common duct cancer. Cancer originating in the sweat glands usually appears near the skin and in the axilla and is particularly

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