In a communication before the Twelfth Congress of Physiology at Stockholm, Sweden, and in many subsequent papers, the Hungarian pharmacologist Mansfeld reported that he had observed a decrease of the blood sugar level after massive ligature of a part of the pancreas in which the circulation in the blood vessels was maintained. The decrease was more marked after two to three days of fasting (Karenzhypoglykämie), and blood sugar curves after administration of dextrose indicated a better carbohydrate tolerance. On the basis of these findings, Linhardt and Hüttl1 performed the operation in man with satisfactory results, which were later confirmed by de Takáts2 and Wilder, who isolated with the thermocautery a piece of the pancreas of a 13 year old boy.
Thus the idea of a surgical cure of diabetes mellitus arose and gradually made progress. Returning to the argument today, I am sorry to say that the theoretic
LJVRAGA P. SURGICAL TREATMENT OF DIABETES MELLITUSBILATERAL SECTION OF THE SPLANCHNIC NERVE AND DENERVATION OF THE LIVER. Arch Surg. 1939;38(1):55-78. doi:10.1001/archsurg.1939.01200070058004