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Article
August 1939

SULFAPYRIDINE IN TREATMENT OF PNEUMONIA, WITH SPECIAL REFERENCE TO POSTOPERATIVE PNEUMONIA

Author Affiliations

ROCHESTER, MINN.
From the Division of Medicine, the Mayo Clinic.

Arch Surg. 1939;39(2):275-281. doi:10.1001/archsurg.1939.01200140107010

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Abstract

No report has come to our attention concerning the effect of sulfapyridine (2-[paraaminobenzenesulfonamido]-pyridine) on postoperative pneumonia. We wish to record our experience with this drug in 21 cases of postoperative pneumonia and 6 cases of primary pneumonia. This includes the cases of all patients with uncomplicated pneumonia under our personal supervision to whom we have given the drug up to the time of writing this report.

DOSE  Patients usually were given 15 grains (1 Gm.) of sulfapyridine by mouth every four hours day and night (90 grains, or 6 Gm., per day). The first dose, and sometimes the second dose also, was doubled, making a total of either 105 or 120 grains (7 or 8 Gm.) during the first twenty-four hours. The duration of treatment is indicated in the charts.

UNFAVORABLE EFFECTS  No seriously bad results could be attributed to treatment with sulfapyridine. Significant leukopenia was not observed. Marked cyanosis

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