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Article
April 1940

RELATION OF TUMORS OF LATERAL ABERRANT THYROID TISSUE TO MALIGNANT DISEASE OF THE THYROID GLAND

Author Affiliations

SAN FRANCISCO
From the Department of Surgery, University of California Medical School.

Arch Surg. 1940;40(4):606-645. doi:10.1001/archsurg.1940.04080030024002
Abstract

Tumors of lateral aberrant thyroid tissue offer a particularly fruitful field for the investigator interested in the origins of cancer. In some of the earliest reports of this condition, Hinterstoisser1 pointed out that the tendency to malignant degeneration in these primarily benign tumors is great. When one considers the fact that the dividing line between innocent and malignant tumors is nowhere less sharply drawn than in tumors of thyroid tissue showing the papillary design, it will be seen that intriguing opportunities are offered in the study of this group of neoplasms. Most investigators agree as to the possibility of malignant change, but there is considerable difference of opinion as to the point at which malignancy begins, the criteria of malignancy and the degree of malignancy, once the diagnosis is established. Dunhill2 wrote: "It would seem that these misplaced bits of tissue, whether in the lateral triangle of the

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