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Article
July 1940

EFFECTS OF LOCAL REACTION IN SPONTANEOUS TUMORS OF ANIMALS AND HUMAN BEINGS

Arch Surg. 1940;41(1):79-90. doi:10.1001/archsurg.1940.01210010082006
Abstract

It has been shown elsewhere1 that temporary asphyxia produced by local ligation damages tumors selectively, in such a manner as to cause extensive and sometimes complete necrosis of the tumor while the normal tissues are unharmed except for transitory inflammation. These results (with transplanted tumors of rats and mice) were substantially duplicated with the chicken sarcoma,2 which is composed of autogenous cells, but the persistence of the chemical excitant was assumed to be responsible for the trivial number of actual cures in proportion to recurrences and deaths. It was obviously desirable to extend the trials of asphyxia to tumors native to the mammalian body. Circumstances unfortunately did not warrant undertaking the chemical production of tumors with tar derivatives. A number of rat and mouse tumors were obtained by special arrangements with large dealers.

1. RAT FIBROMA  This is a common benign growth which develops slowly to huge size,

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