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Article
July 1941

FUNCTIONAL EFFECT OF NEO-SYNEPHRIN ON THE ANESTHETIZED DOGOBSERVATIONS OF BLOOD PRESSURE, PULSE, RESPIRATION AND FLOW OF URINE AND BILE

Author Affiliations

KANSAS CITY, KAN.
From the Hixon Laboratory for Medical Research, the University of Kansas.

Arch Surg. 1941;43(1):94-100. doi:10.1001/archsurg.1941.01210130097008
Abstract

Since Tainter and Stockton's1 original report on the effectiveness of neo-synephrin as a systemic vasoconstrictor stimulant, its use as a vasopressor drug for spinal anesthesia has been reported by numerous investigators.2 These workers have reported its effect in elevating and sustaining the blood pressure during spinal anesthesia. The associated bradycardia has also been discussed thoroughly.

The action of neo-synephrin on the respiration has been briefly commented on by Tainter and Throndson3 and by Tainter, Throndson and Moose4 in conjunction with its use in solutions of procaine hydrochloride as a local anesthetic for dental nerve blocking. Their results indicated that the action of neo-synephrin on the respiration is not of great clinical significance.

Data relative to the effects of neo-synephrin on urinary excretion are meager. Boyd5 reported that 0.5 cc. of a 0.01 per cent solution of neosynephrin hydrochloride caused a marked antidiuretic action analogous to

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