Increasing knowledge of the physiology of the liver has established the vital importance of the integrity of this organ for normal body activity and economy. Moreover, it has awakened a keener appreciation of the potential effects of disturbed hepatic function, especially as it relates to disorders of digestion and metabolism. Nevertheless, the clinical recognition of disease of the liver has attained a relatively high degree of accuracy only with regard to the advanced or the terminal stages of such disease. The early and mild forms frequently remain undiagnosed and are accorded little if any consideration. Present day tests of liver function are, with rare exceptions,1 of limited diagnostic value in cases of early or mild involvement, owing to the remarkable regenerative capacity and functional reserve with which the liver is endowed.
Recently Hanger2 observed that the serums of patients with disease of the liver are capable of flocculating
ROSENBERG DH. THE CEPHALIN-CHOLESTEROL FLOCCULATION TEST IN CASES OF DISEASE OF THE LIVERWITH SPECIAL REFERENCE TO THE DIAGNOSIS OF MILD AND UNSUSPECTED FORMS. Arch Surg. 1941;43(2):231-248. doi:10.1001/archsurg.1941.01210140065006