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Article
September 1941

HISTOLOGIC DISTRIBUTION OF VITAMIN A IN BIOPSY SPECIMENS OF THE LIVER

Author Affiliations

CHICAGO
Research Fellow of the Cook County Graduate School of Medicine.; From the Cook County Hospital and the Cook County Graduate School of Medicine.

Arch Surg. 1941;43(3):376-385. doi:10.1001/archsurg.1941.01210150052003
Abstract

The use of the fluorescence microscope permits the histologic visualization of vitamin A in tissues.1 The results of recent investigations on the histologic distribution of vitamin A in the livers of human beings and of animals under normal and under pathologic conditions have been reported.2 In these studies the human tissues examined were obtained at autopsy. Two objections may be raised against the results: 1. Postmortem changes may influence the picture, although no evidence of changes occurring in the first twelve hours after death was obtained in animal experiments. 2. The antemortem conditions and the irregular intake of food prior to death may influence the amount and the distribution of vitamin A. The purpose of this paper is to report on a study of the vitamin A fluorescence in specimens of human livers obtained at operation in order (1) to investigate the significance of the foregoing objections, (2)

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