In 1940 we presented two papers1 on the use of heparin in the prevention of peritoneal adhesions in the dog. In these reports it was shown that the reformation rate of adhesions after the intraperitoneal administration of effective doses of heparin was in the neighborhood of 30 per cent, while the average reformation rate among controls was 147 per cent. Since the publication of these papers, laboratory experimentation has been continued, and an extensive series of experiments will be reported elsewhere. It can be stated here that these experiments confirm the conclusions in the reports of our earlier work. It is our opinion that this method of diminishing the number of reformed adhesions after division is theoretically sound, and it has been proved to be practically effective in the dog.
The mechanism of this effectiveness is believed to consist in the diminution of the coagulability of the serous exudate
LEHMAN EP, BOYS F. CLINICAL USE OF HEPARIN IN THE PERITONEUM FOR THE PREVENTION OF ADHESIONSREPORT OF FOURTEEN CASES. Arch Surg. 1941;43(6):933-945. doi:10.1001/archsurg.1941.01210180002001