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Article
February 1942

VALUE OF CHEMOTHERAPY IN THE TREATMENT OF OSTEOMYELITIS

Arch Surg. 1942;44(2):234-259. doi:10.1001/archsurg.1942.01210200050005
Abstract

This communication concerning the clinical effect of sulfanilamide and its derivatives as chemotherapeutic aids in the treatment of the various forms of osteomyelitis contains: (1) a résumé of the technical information necessary for the use of these drugs; (2) a résumé of clinical factual experience; (3) a discussion of these facts based on the causative mechanism, the development and the pathology of osteomyelitis and the biologic mechanism according to which these drugs produce their effects; (4) a summary of the conclusions to which these résumés necessarily lead regarding the efficacy of present day chemotherapy.

TECHNICAL INFORMATION NEEDED IN THE ADMINISTRATION OF SULFANILAMIDE AND ITS DERIVATIVES 

General Administration.  —(a) Administration by Mouth: Administration of sulfanilamide and its derivatives by mouth is the method most commonly employed, and its general principles are so well known that there is no need of repetition. Suffice it to emphasize that in the beginning the

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