Numerous experimental methods are known which lead to ulceration of the stomach. Of these methods, the greatest significance is attached to those employed by Exalto, Mann, Ivy, Dragstedt and others, who produced chronic peptic ulcer by experimental alterations in gastro-intestinal function. The ulcer thus produced resembles grossly and histologically the clinical lesion, and both respond in a similar manner to therapy. From such studies more is already known regarding the basic factors causing or curing the experimental lesion than those influencing the spontaneous ulcer, and the information available with respect to both lesions exceeds that regarding ulcer in other and frequently more accessible portions of the body.
The studies on experimentally produced ulcers have greatly revived interest in the fundamental ulcer problems—why ulcers form, become chronic, undergo hemorrhage or perforate and how they can be prevented or healed. So far, the investigations have been most fruitful in establishing the fundamental
QUIGLEY JP. MOTOR PHYSIOLOGY OF THE STOMACH, THE PYLORUS AND THE DUODENUMWITH SPECIAL REFERENCE TO GASTRODUODENAL ULCER. Arch Surg. 1942;44(3):414-437. doi:10.1001/archsurg.1942.01210210018002