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August 1942


Arch Surg. 1942;45(2):272-285. doi:10.1001/archsurg.1942.01220020092008

In recent years there have been several attempts made to apply some of the experimental methods for the prevention of shock in animals to practical use in human beings. Many of these have taken the form of direct replacement of liquid to make up for the loss of circulating blood volume. Others have depended on the use of adrenocortical substances, for the value of which some observers1 have made important claims.

That adrenocortical substances might have considerable value in the prevention or the treatment of shock is suggested by a large amount of clinical, pathologic and experimental data gathered by many different observers. Thus Short2 suggested the theory that failure of the adrenal glands, which play an important role in the maintenance of vessel tone, precipitates the state of shock. Swingle and associates3 showed that adrenalectomized dogs maintained in normal health and vigor by injections of adrenal

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