From the standpoint of the frequency of clinical occurrence, the most susceptible of the areas subject to the ulcerating influences of the acid gastric juice is the first part of the duodenum. Yet, there is little information available regarding the acidity in this important ulcer-bearing region in marked contrast with the extensive studies made on acidity in the stomach.
The study to be reported was undertaken to obtain data on acidity in the duodenal bulb under fasting conditions in patients with an ulcer at that site for comparison with comparable data obtained during digestion in the same subjects1 and with data from fasting normal subjects.2 The results will widen the knowledge of the trend of events in the duodenal bulb and should enable further appraisal of the relation between the acidity in this area and that simultaneously observed in the stomach. The comparisons, we hope, will shed more
BERK JE, REHFUSS ME, THOMAS JE. DUODENAL BULB ACIDITY UNDER FASTING CONDITIONS IN PATIENTS WITH DUODENAL ULCER. Arch Surg. 1942;45(3):406-415. doi:10.1001/archsurg.1942.01220030073004