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Article
September 1942

CAPILLARY PERMEABILITY AND INFLAMMATION IN THE SKIN OF RABBITSEXPERIMENTAL STUDIES FOLLOWING SECTIONING OF THE SPINAL CORD

Author Affiliations

MEMPHIS, TENN.
From the Departments of Surgery and Pathology, the University of Tennessee College of Medicine.

Arch Surg. 1942;45(3):416-423. doi:10.1001/archsurg.1942.01220030083005
Abstract

Lauer1 recently stated that the intensity of the inflammatory reaction was diminished after sectioning the spinal cord. The reactions, however, were similar above and below the injured segment of the cord. The similarity of these two inflammatory reactions, therefore, would make it impossible to ascribe this diminished reaction either to the separation of the organ from its nervous centers or to the loss of pain sensations.

Capillary permeability and inflammation in the skin of the rabbit have been studied by one of us (R. H. R.2). The technic used in these studies consisted of applying xylene to the shaven skin of the rabbit at intervals preceding the intravenous injection of trypan blue. A definite pattern of localization of dye occurred in the xylene-treated areas. This dye localized first and in the largest quantity in the area where xylene was applied the shortest time before the dye was injected.

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