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Article
October 1942

PROGRESS IN ORTHOPEDIC SURGERY FOR 1941A REVIEW PREPARED BY AN EDITORIAL BOARD OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

Arch Surg. 1942;45(4):653-690. doi:10.1001/archsurg.1942.01220040149016
Abstract

III. CONGENITAL DEFORMITIES 

Experimental.  —The occurrence of skeletal abnormalities in the offspring of rats reared on a deficient diet is reported on by Warkany and Nelson.116 They fed albino rats of the Sprague-Dawley strain which were entirely free of abnormalities a diet composed of yellow corn meal (76 per cent), wheat gluten (20 per cent), calcium carbonate (3 per cent) and sodium chloride (1 per cent) with sufficient viosterol. Multiple skeletal abnormalities appeared in the offspring. These consisted of shortening or absence of the tibia, the fibula, the radius, the ulna and the bones of the hands and the hind feet; shortening of the mandible; fusion of the ribs, and various deformities of the sternum, the maxilla, the clavicle and the scapula. These abnormalities were not present if pig liver (2 per cent) was added to the diet. [Ed. Note: One of us (J. H. K.) has had the

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