—McDonald, Doss and Thompson30 feel that the diagnosis of sarcoma of the urinary bladder should be arrived at cautiously because of the possibility that a neoplasm of epithelial origin may be masquerading as one of mesodermal origin. They studied tumorous tissue obtained in 9 cases in which the diagnosis of sarcoma of the urinary bladder had been made, either with or without the coincidental presence of carcinoma, and were able to demonstrate the epithelial origin of all 9 tumors. McDonald, Doss and Thompson also were able to show that the carcinoma cells had assumed characteristics which, if examined histologically, were diagnostic of sarcoma. The short clinical history and poor results (all patients died of the disease, and only 1 lived longer than a year after the neoplasm had been first recognized) attest to the extremely malignant nature of all lesions of this type in the urinary bladder.
SCHOLL AJ, HINMAN F, VON LICHTENBERG A, HEPLER AB, GUTIERREZ R, THOMPSON GJ, PRIESTLEY JT, WILDBOLZ E, O'CONOR VJ. REVIEW OF UROLOGIC SURGERY. Arch Surg. 1943;46(1):138-166. doi:10.1001/archsurg.1943.01220070141008