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Article
July 1943

INFLUENCE OF HEPATIC FUNCTION ON METABOLISM OF VITAMIN A

Author Affiliations

CHICAGO
From the Cook County Hospital, the Department of Surgery, Northwestern University, and the Department of Internal Medicine and Pathology, University of Illinois College of Medicine, and the Cook County Graduate School of Medicine.

Arch Surg. 1943;47(1):26-43. doi:10.1001/archsurg.1943.01220130029005
Abstract

Many facts indicate an influence of the liver on the metabolism of vitamin A. In acute1 and chronic2 hepatic disease the vitamin A content of the blood is low. Night blindness due to deficiency of vitamin A has been reported in acute hepatitis3 and in cirrhosis even without jaundice.4 The vitamin A content of the liver is low in chronic hepatitides (cirrhoses)5 and variable in acute hepatitis and in catarrhal or arsphenamine jaundice.6 The histologic distribution of vitamin A in the liver is considerably changed by damage to the liver.7 Several factors have been mentioned to explain the foregoing observations, such as: (1) faulty absorption of vitamin A and especially of carotene from the intestinal tract8; (2) inability of the liver to store vitamin A, although more emphasis is laid on alterations of the reticuloendothelial system than on damage to the hepatic

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