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Article
October 1943

EFFECT OF SULFATHIAZOLE ADMINISTERED ORALLY AND SULFANILAMIDE IMPLANTED LOCALLY ON CONTAMINATED WOUNDSEXPERIMENTAL STUDY

Author Affiliations

NEW YORK
From the Departments of Surgery, Presbyterian Hospital, Columbia University, College of Physicians and Surgeons and the New York Hospital, Cornell University Medical College.

Arch Surg. 1943;47(4):352-358. doi:10.1001/archsurg.1943.01220160036005
Abstract

During a study1 of the nonsuture method of bridging a gap in the severed femoral artery of the dog, data were accumulated concerning the value of sulfanilamide implanted locally into the wound and also concerning the usefulness of sulfathiazole administered orally. Although the number of the experiments in which analysis of the data has been made is not large, the extensive nature of the experimental procedure plus the controlled condition of the operations make it worth while to report the results.

METHOD  After some 80 preliminary operations an exact technic was adopted, and with the time relations standardized a series of 30 carefully controlled operations were performed. In 20 animals the following procedure was followed: The right femoral artery was exposed under unsterile conditions, the incision being exactly 10 cm. in length. The artery was isolated for 2 cm. and divided between transfixion ligatures. All bleeders were clamped and

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