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Article
June 1944

ROLE OF ALLERGY IN DELAYED HEALING AND IN DISRUPTION OF WOUNDSII. EFFECT OF SPECIFIC SENSITIVITY TO CATGUT ON REACTION OF TISSUES TO CATGUT SUTURES AND ON HEALING OF WOUNDS IN THE PRESENCE OF CATGUT SUTURES

Author Affiliations

CHICAGO
From the Department of Pathology, University of Chicago.

Arch Surg. 1944;48(6):445-449. doi:10.1001/archsurg.1944.01230010458004
Abstract

In a previous report1 the general problem of delayed healing and disruption of wounds was discussed and experimental evidence was given to support the fact that hypersensitivity to catgut can be produced in animals by adequate antigenic stimulation. The experiments to be described in this paper were designed to evaluate the effects of such hypersensitivity on the reaction of tissues to catgut sutures and on the healing of surgical wounds repaired with catgut.

MATERIAL AND METHOD  Eighty-eight rabbits were used in this study. Plain and chromicized catgut, sizes no. 0 and no. 1, were used throughout the experiments. In all operative procedures the technics commonly used in surgical practice were employed to maintain asepsis. Operative sites were carefully prepared by shaving, scrubbing with soap and water and thoroughly cleansing with a solution of 1 per cent iodine in 70 per cent alcohol. Laparotomies were done with the animals under

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