It is now generally accepted that penicillin is the most effective chemotherapeutic agent yet discovered for the treatment of staphylococcic infections. In view of this fact, a critical study of its action on chronic osteomyelitis should be of value.
Such a study should have two aims: one to evaluate the effectiveness of penicillin for this disease and the other to determine, if possible, the most satisfactory method of employing this new therapeutic agent. In any study of chronic osteomyelitis, prolonged observation of patients after the completion of treatment is necessary before final conclusions can be established.
Several reports have now been published in which reference has been made to the use of penicillin for chronic osteomyelitis.1 These reports have been concerned chiefly with a description of the immediate effect of penicillin. There has been no report as yet of a series of cases in which it has been possible
ANDERSON DG, HOWARD LG, RAMMELKAMP CH. PENICILLIN IN THE TREATMENT OF CHRONIC OSTEOMYELITISA REPORT OF FORTY CASES. Arch Surg. 1944;49(4):245-257. doi:10.1001/archsurg.1944.01230020253007