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Article
November 1944

PROGRESS IN ORTHOPEDIC SURGERY FOR 1943 A REVIEW PREPARED BY AN EDITORIAL BOARD OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONSXIII. TUBERCULOSIS OF BONES AND JOINTS

Arch Surg. 1944;49(5):356-357. doi:10.1001/archsurg.1944.01230020365008
Abstract

In a study by Tytler and Lapp,481 promin (sodium salt of p,p′-diamino-diphenylsulfone-N-N′-didextrose sulfonate) in a concentration of 5 per cent in a medium of tragacanth jelly was repeatedly injected, after aspiration of pus, into tuberculous abscesses and sinus tracts of 10 patients. The abscesses treated were in the following regions: 4 in the lumbar region, 2 in the groin, 1 in the low dorsal region, 1 in the axillary region, 1 in the right ilium and 1 in the neck. While the results were somewhat irregular, the clinical opinion was formed that improvement in all patients was greater or more rapid than would have been expected with orthodox methods. It is thought that these results justify a more extensive trial of the drug by local application to suitable lesions and possibly by injection into more deep-seated lesions.

Callomon482 found that experimental tuberculosis of guinea pigs was apparently somewhat

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