McIntosh and Selbie558 point out that in a previous paper they showed the value of sulfonamide drugs in preventing gas gangrene in mice under certain conditions. This report is based on a further study of the subject, in which they used zinc peroxide, proflavine and penicillin on experimental animals.
They point out that the clostridiums are in the nesting stage when the wound is infected and that only through the use of some inciting agent, which would appear to be the calcium ion, is the organism capable of producing an infection. In their experiments toxin-free clostridiums were used, and with the calcium chloride present they produced both a local and a general infection. With this technic, they found that in local infection zinc peroxide is apparently of no value in preventing the development of Clostridium welchii infection in mice after the organisms have invaded the tissues.
Proflavine was of
COLONNA PC. PROGRESS IN ORTHOPEDIC SURGERY FOR 1943 A REVIEW PREPARED BY AN EDITORIAL BOARD OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONSXVII. INFECTIONS OF BONES AND JOINTS. Arch Surg. 1944;49(6):402-414. doi:10.1001/archsurg.1944.01230020412006