[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
February 1945


Author Affiliations

From the Division of Neurological Surgery and the Otho S. A. Sprague Memorial Institute, the University of Chicago.

Arch Surg. 1945;50(2):69-73. doi:10.1001/archsurg.1945.01230030074003

Reports on intrathecal administration of penicillin in treating infections of the central nervous system are becoming numerous. Recently intraventricular injection of penicillin has been employed when meningitis did not respond to parenteral or intrathecal modes of administration.1 The direct application of penicillin to wounds of the cerebral cortex in the treatment of injury to the head has also been suggested.2 Our interest in the effect of penicillin on the central nervous system was aroused by observing convulsive seizures following intraventricular injection of the drug in a case of ventriculitis.3 Experiments were then planned to investigate the effect of the drug when administered intracisternally, intraventricularly and locally to the cerebral cortex either by application to the subdural space or by intracortical injection. Such experiments were performed, and it was observed that certain doses of penicillin so administered to mice, cats, dogs and monkeys gave rise to convulsive manifestations.

First Page Preview View Large
First page PDF preview
First page PDF preview