Barr, Lingley and Gall679 found the growing epiphysial plate of the albino rat extremely sensitive to roentgen irradiation. They observed the effect of irradiation on one knee joint of albino rats 30, 90 and 160 days old. The resultant changes were studied histologically and roentgenographically. The skin, subcutaneous tissue. muscles, synovia and articular cartilage showed insignificant transitory changes. On the bone marrow irradiation produced depletion of approximately one half or less of the marrow cellular content in the field of irradiation within two to three weeks; the cellular content returned to a normal level in the succeeding two to four weeks.
Doses of 665 to 1,165 r produced moderately severe histologic changes in the epiphysial plate, while doses of 1,335 to 1,800 r caused severe injury, as evidenced by disruption of columns of cartilage cells and destruction of chondrocytes. There was no evidence indicating stimulation, and only inconsequentially was
STEINDLER A. PROGRESS IN ORTHOPEDIC SURGERY FOR 1943 A REVIEW PREPARED BY AN EDITORIAL BOARD OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONSXIX. RESEARCH. Arch Surg. 1945;50(2):97-102. doi:10.1001/archsurg.1945.01230030102009