In 1926 Davidson1 demonstrated that severely burned patients excrete abnormally large amounts of nitrogen in the urine, a finding which has been confirmed by other investigators.2 Although the existence of this abnormality of protein metabolism in burned patients has been well established, its mechanism is not understood, nor is there much information regarding the means of preventing or compensating for this destruction of body protein. The present study was undertaken to obtain more information about the change in protein metabolism in burned patients. It was planned to correlate the nitrogen balance of patients on various diets with the urinary excretion of 17-keto steroids, cortin-like substances, gonadotropins and estrogens. The purpose of this paper is to present studies on the nitrogen balance of 23 patients; the data on the endocrine changes in these patients will be presented elsewhere.
MATERIALS AND METHODS
A ward of four beds with an adjoining
HIRSHFELD JW, ABBOTT WE, PILLING MA, HELLER CG, MEYER F, WILLIAMS HH, RICHARDS AJ, OBI R. METABOLIC ALTERATIONS FOLLOWING THERMAL BURNSIII. EFFECT OF VARIATIONS IN FOOD INTAKE ON NITROGEN BALANCE OF BURNED PATIENTS. Arch Surg. 1945;50(4):194-200. doi:10.1001/archsurg.1945.01230030202003