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Article
April 1945

METABOLIC ALTERATIONS FOLLOWING THERMAL BURNSIII. EFFECT OF VARIATIONS IN FOOD INTAKE ON NITROGEN BALANCE OF BURNED PATIENTS

Author Affiliations

DETROIT
Present address: Department of Internal Medicine, University of Oregon Medical School.; From the Departments of Surgery and Internal Medicine, Wayne University College of Medicine, and the Divisions of Surgery and Internal Medicine, City of Detroit Receiving Hospital (Dr. Hirshfeld, Dr. Abbott, Dr. Pilling, Dr. Heller and Dr. Meyer), and the Research Laboratory, the Children's Fund of Michigan (Dr. Williams, Mr. Richards and Mr. Obi).

Arch Surg. 1945;50(4):194-200. doi:10.1001/archsurg.1945.01230030202003
Abstract

In 1926 Davidson1 demonstrated that severely burned patients excrete abnormally large amounts of nitrogen in the urine, a finding which has been confirmed by other investigators.2 Although the existence of this abnormality of protein metabolism in burned patients has been well established, its mechanism is not understood, nor is there much information regarding the means of preventing or compensating for this destruction of body protein. The present study was undertaken to obtain more information about the change in protein metabolism in burned patients. It was planned to correlate the nitrogen balance of patients on various diets with the urinary excretion of 17-keto steroids, cortin-like substances, gonadotropins and estrogens. The purpose of this paper is to present studies on the nitrogen balance of 23 patients; the data on the endocrine changes in these patients will be presented elsewhere.

MATERIALS AND METHODS  A ward of four beds with an adjoining

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