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Article
July 1945

PENICILLINITS TOPICAL USE AS A BACTERIOSTATIC AGENT FOR THE PALLIATIVE TREATMENT OF CHRONIC STASIS ULCERS OF THE LOWER EXTREMITIES

Author Affiliations

DURHAM, N. C.
From the Department of Surgery, Duke University School of Medicine and Duke Hospital.

Arch Surg. 1945;51(1):22-27. doi:10.1001/archsurg.1945.01230040025003
Abstract

Chronic stasis ulcers of the lower extremities are a frequent complication of varicose veins and thrombophlebitis. In the presence of chronic venous stasis the skin shows nutritional disturbances, such as atrophy, pigmentation and induration. An ulcer usually develops at the site of previous pigmentation and induration or occurs suddenly after thrombosis of a cutaneous vein, over which the skin ulcerates. Slight trauma may be the immediate cause of such an ulcer. In the early acute stages these ulcers fail to heal, because of anoxemia due to stasis and secondary infection. When they become chronic, an additional factor, i. e., poor local arterial blood supply, prevents spontaneous healing. All types of treatment are directed toward relieving the venous hydrostatic pressure and reducing the local infection. The palliative methods used for the ambulatory patient accomplish this by elastic support of the extremity and topical application of a bacteriostatic agent. The organism commonly

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