THESE experiments were begun several years ago, at the time that Dr. Helen Taussig and I became interested in the question whether increase of the blood supply to the lungs by the creation of an artificial ductus arteriosus would benefit patients with the tetralogy of Fallot or pulmonary stenosis. It is obvious that it would have been desirable to reproduce experimentally the combination of defects which are found in the tetralogy of Fallot. Since there is no known method by which this can be done, the initial efforts consisted in many attempts to produce pulmonary stenosis of severe degree. These experiments met with little success and will not be described in great detail. It was then decided to attempt to produce unsaturation of the arterial blood by the removal of pulmonary tissue combined with the creation of a pulmonary arteriovenous fistula.
ATTEMPTS TO PRODUCE STENOSIS OF THE PULMONARY ARTERY
BLALOCK A. EFFECTS OF AN ARTIFICIAL DUCTUS ARTERIOSUS ON EXPERIMENTAL CYANOSIS AND ANOXEMIA. Arch Surg. 1946;52(3):247-252. doi:10.1001/archsurg.1946.01230050252001