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May 1946

ANAPHYLAXIS-LIKE REACTIONS PRODUCED BY ASCARIS EXTRACTSI. The Changes in the Histamine Content and the Coagulability of the Blood in Guinea Pigs and in Dogs

Author Affiliations

From the Department of Biochemistry and Pharmacodynamics, Instituto Biologico.

Arch Surg. 1946;52(5):523-537. doi:10.1001/archsurg.1946.01230050531002

IN a preceding paper, we have studied1 the mechanism of shock produced by hydatid fluid (Taenia echinococcus) when injected into dogs. We have reached the conclusion that the material responsible for the shock is not precipitated by 5 per cent trichloroacetic acid, does not dialyze through cellophane paper and resists boiling temperature for a long time. From those preliminary studies we have been able to obtain a fairly purified material which produces profound shock in dogs. This shock is of the indirect type, since a second injection of the same material does not produce any appreciable effect (desensitization). Furthermore, in certain cases there occurred an evanescent incoagulability of the blood and in a few animals complete incoagulability was observed, suggesting a liberation of heparin from tissues into the blood stream. Histamine was found to be increased in the circulating blood in a few animals but in most of the

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